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Record number:
2125
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Incidence of postdonation hypertension, risk factors associated with its development, and impact of type of treatment received on renal outcomes were determined in 3700 kidney donors. After a mean (standard deviation [SD]) of 16.6 (11.9) years of follow-up, 1126 (30%) living kidney donors developed hypertension and 894 with known antihypertensive medications. Hypertension was associated with proteinuria, eGFR < 30, 45, and 60 mL/min/1.73m2, CVD and death. Blood pressure was <140/90 mm Hg at last follow-up in 75% of hypertensive donors.
Time to detection:
Hypertension developed in 4%, 10%, and 51% at 5, 10, and 40 years
Alerting signals, symptoms, evidence of occurrence:
Hypertension
Demonstration of imputability or root cause:
In this predominantly Caucasian cohort, hypertension is common after donation (30%) and is well controlled in most donors. Older age, family history of hypertension, higher BMI, higher fasting serum glucose, higher systolic blood pressure, higher diastolic blood pressure, hyperlipidemia, and being a smoker were associated with a higher risk of incident hypertension.
Groups audience:
Keywords:
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Hypertension, living donation, risk, kidney transplantation
Reference attachment:
Suggest references:
Hypertension after kidney donation: Incidence, predictors and correlates. Sanchez et al. Am J Transplant. 2018 Oct;18(10):2534-2543
Expert comments for publication:
Hypertensive risk after living kidney donation needs to be studied in other ethnic groups. Factors associated with its development are similar to those in the general population. Also, it should be particularly evaluated and followed-up in donors with hypertensive status before living donation in order to prevent complications.