Editorial: Cancer Risk in Kidney Transplant Recipients (2020)

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Time to detection: 
Alerting signals, symptoms, evidence of occurrence: 
Demonstration of imputability or root cause: 
Groups audience: 
Suggest new keywords: 
Kidney transplant
Kidney recipient
Kidney transplantation
Therapy not discussed
Renal cell carcinoma
Astrocytoma/glioblastoma multiforme
Suggest references: 
Irish GL, Coates PT, Clayton PA. Cancer post kidney transplant: the question of risk. J Nephrol. 2020 Dec;33(6):1129-1131. doi: 10.1007/s40620-020-00802-4. PMID: 33108603. Eccher A, Girolami I, Motter JD, Marletta S, Gambaro G, Momo REN, Nacchia F, Donato P, Boschiero L, Boggi U, Lombardini L, Cardillo M, D'Errico A, Neil D, Segev DL, Zaza G. Donor-transmitted cancer in kidney transplant recipients: a systematic review. J Nephrol. 2020 Dec;33(6):1321-1332. doi: 10.1007/s40620-020-00775-4. Epub 2020 Jun 13. PMID: 32535833; PMCID: PMC7701067.
First review MN 5/31/22 Second review 10/26
Expert comments for publication: 
This editorial comments on the 2020 systematic review by Eccher et al. on transmission of donor cancer to kidney recipients (NOTIFY record #2187, reference above). In addition to summarizing several findings of that paper, the authors present a discussion of additional factors to consider when considering use of an organ from a donor who presents a risk of malignancy transmission. These include such things as poor quality of life on dialysis, high sensitization status, lack of vascular access. They also comment on the balance between a risk of cancer transmission versus risk of morbidity and mortality from continued dialysis, especially in the older patient population. These are some factors should be considered on an individual basis in addition to the published statistical risk factors for tumor transmission and the authors stress consideration of individual patient factors. They also note an increased standardized mortality ratio for death from cancer 10 years post kidney transplant for younger as opposed to older age groups and suggest particular vigilance for this population. (The editorial also discusses a separate publication in the same issue regarding kidney transplants in recipients with a history of malignancy) (Tessari G, Maggiore U, Zaza G, Momo REN, Nacchia F, Boschiero L et al. Mortality from cancer is not increased in elderly kidney transplant recipients compared to the general population. A competing risk analysis. J Nephrol 2020 Dec;33(6):1309-1319.