Unstable angina in a PBSC donor

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Uncommon; the authors found in 1/162 (0,6%)
Time to detection: 
Six hours after 2nd and 3rd dose of G-CSF.
Alerting signals, symptoms, evidence of occurrence: 
Donor experienced palpitations and mild chest discomfort (signs of cardiac ischemia).
Demonstration of imputability or root cause: 
G-CSF can influence platelet aggregation. The role of G-CSF in the development of this donor's cardiac ischemia is unclear, however the onset of cardiac ischemia within six hours of G-CSF administration suggests a potential causal relationship. The donor was found to have (unreported) symptoms of cardiac artery disease prior to G-CSF administration and was therefor at risk.
Groups audience: 
Suggest new keywords: 
cardiac artery disease
platelet aggregation
Suggest references: 
Unstable Angina in a Peripheral Blood Stem and Progenitor Cell Donor Given Granulocyte-Colony-Stimulating Factor. R Vij et al, Transfusion.1999 May;39(5):542-3
Expert comments for publication: 
Donors with mild symptoms that show risk of cardic artery dissease should be closely monitored when given G-CSF.