Severe hypoxemia in a healthy HSC donor

Status:

Ready to upload

Record number:

2090

Adverse Occurrence type:

MPHO Type:

Estimated frequency:

Uncommon

Time to detection:

Within 1 hour of GCSF injection

Alerting signals, symptoms, evidence of occurrence:

Cough and dyspnoea. Low oxygen saturations.

Demonstration of imputability or root cause:

Temporal association to GCSF injection. Excluding other causes.

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Keywords:

PBSC (peripheral blood stem cells)

G-CSF (granulocyte colony-stimulating factor)

References:

Severe Hypoxemia in a Healthy Donor for Allogeneic Hematopoietic Stem Cell Transplantation After Only the First Administration of Granulocyte-Colony Stimulating Factor

Reference attachment:

2090_Severe Hypoxemia, Yamamoto et al.pdf

Suggest references:

Severe Hypoxemia in a Healthy Donor for Allogeneic Hematopoietic Stem Cell Transplantation After Only the First Administration of Granulocyte-Colony Stimulating Factor, Yamamoto et al, Transfus Med Hemother. 2016 Nov;43(6):433-435

Note:

I think that this publication should be added to the existing section on allergy to GCSF, it should not have a category by itself