Long-term acquisition of allergen-specific IgE and asthma following BMT

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Known, not uncommon.
Time to detection: 
One to multiple years after post bone marrow transplantation.
Alerting signals, symptoms, evidence of occurrence: 
Development of allergic rhinitis; newly acquired asthma; positive prick skin tests.
Demonstration of imputability or root cause: 
Group of 12 BMT recipients and donors, of which 5 pairs were evaluated. Prior to BMT D/R paris had skin prick testing to 17 aeroallergens. Testing repeated in recipients on day 30, 100, 1 year and annually (14 years). All donors were known with moderate-to-severe allegic disease and elevated allergen-specific IgE. Total IgE increased in recipients. Allergen-specific IgE to D farinae was demonstrated in 3/5 donors and newly acquired in 2 of 3 recipients from these donors.Four patients developed asthma and reported seasonal variability in symptoms.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest references: 
Long-term acquisition of allergen-specific IgE and asthma following allogeneic bone marrow transplantation from allergic donors. Teal S. Hallstrand et al, BLOOD, 15 NOVEMBER 2004