Adverse Occurrence type:
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
Eczematous plaques and nodules on the lower part of both legs, similar to donor who died 1 month prior of lymphoma. Atypical T cells infiltrating the dermis and subcutis. In retrospect, lesion had been there for 1 year.
Demonstration of imputability or root cause:
Histologic examination of a nodule revealed many similarities to the subcutaneous panniculitic T-cell lymphoma identified in the donor. Microsatellite PCR identity between donor and recipient tumors. TCRgamma sequence identity.
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