Status:
Ready to upload
Record number:
1994
Adverse Occurrence type:
MPHO Type:
Time to detection:
N/A: No tumor seen at 14-68 months followup
Alerting signals, symptoms, evidence of occurrence:
None. This small series summarizes several tumor types that were not transmitted to recipients. In 4 cases, renal cell carcinoma was found after the livers had been implanted (kidneys were not used). Kidney tumors were 1.0-4.5 cm, all Stage 1. No tumors were transmitted with 14-55 month followup. One donor had prostate carcinoma, 0.5 cm Stage A1 (localized) found at autopsy. The liver recipient did not develop tumor at 62 month followup. One donor had prostate carcinoma (1.3 cm, Stage A1) and glioblastoma found at autopsy. The liver recipient had no tumor at 44 month followup. A right kidney recipient had transplantectomy on day 12, apparently for unrelated reasons, and has not developed tumor at 2 year followup.
Demonstration of imputability or root cause:
N/A
Imputability grade:
Not Assessable
Groups audience:
Keywords:
Suggest new keywords:
Single center series
Deceased donor
Risk of transmission
Liver transplant
Kidney transplant
Astrocytoma/glioblastoma multiforme (WHO grade 4)
Renal cell carcinoma
Prostate adenocarcinoma/carcinoma
Reference attachment:
Suggest references:
Serralta AS, Orbis FC, Sanjuan FR, Moya AH, López-Andújar R, Pareja EI, et al. If the donor had an early-stage genitourinary carcinoma and the liver has already been implanted, should we perform the transplantectomy? Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. 2003;9(12):1281-5.
Note:
Clone of record 1886 (EP)
First review Mike 9/11/18.
Expert comments for publication:
The results of this series are consistent with current thinking that small prostate cancers have minimal to no risk for tumor transmission, and extrarenal organs from donors with small renal cancers also have an extremely low risk of tumor transmission. The kidneys in this series are discarded, although the current trend is to consider resection of small solitary tumors and use of otherwise acceptable kidneys for transplant.