Status:
Ready to upload
Record number:
1856
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Not possible to estimate, since this was an undifferentiated tumor from a 22 year old donor.
Time to detection:
12 hours
Alerting signals, symptoms, evidence of occurrence:
Detected incidentally; allograft pancreatectomy was removed after 12 hours due to intractable hemorrhage. At that time, a 5 mm tumor was found on pathologic analysis and the diagnosis of undifferentiated tumor made. Mention is also made of liver and kidney recipients (below).
Demonstration of imputability or root cause:
Tumor was found in allograft pancreas immediately after transplant. Also, a kidney recipient from the same donor had a nephrectomy approximately 1 year posttransplant when a mass was found by ultrasound; the liver recipient died of metastatic disease. Microscopic examination from both patients showed tumor histologically identical to that seen in the pancreas recipient.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest new keywords:
Malignancy
Case report
Deceased donor
Kidney transplant
Liver transplant
Pancreas transplant
Histologic analysis
Carcinoma of unknown primary site
Reference attachment:
Suggest references:
Wong C, Hold P, Mohteshamzadeh M, Dhanda R, Sells R. Occult donor malignancy in pancreas transplantation. Renal Failure. 2007;29(2):243-4.
Expert comments for publication:
The authors mention that CD117 staining (c-kit) was positive but that this is nonspecific. No further pathologic description is given. At last followup (2.5 years) the pancreas recipient was without evidence of tumor. The discussion stresses the importance of communication among transplant centers when a tumor is discovered. We would also add that communication is important even when a transmitted tumor is simply suspected.