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Adverse Occurrence type:
N/A: Literature review of multiple donor tumor transmission reports and some committee recommendations (UK, DTAC) as of 2014.
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
Demonstration of imputability or root cause:
Suggest new keywords:
Bone marrow allograft transplant
Renal cell carcinoma
Urothelial (transitional cell) carcinoma
Breast cancer, other or type not specified
Leukemia, type not specified
Lymphoma, T cell
Leukemia, myeloid, promyelocytic
Leukemia, myeloid, acute myelogenous
Astrocytoma/glioblastoma multiforme (WHO grade 4)
Pancreatic (ductal) adenocarcinoma
Large bowel adenocarcinoma
Zhang S, Yuan J, Li W, Ye Q. Organ transplantation from donors (cadaveric or living) with a history of malignancy: review of the literature. Transplantation reviews (Orlando, Fla). 2014;28(4):169-75.
If we clone this for all the variables, we will have a library in itself. There are 6 donor types and 14 tumors for a total of 84 combinations. We will need some guidance on how you want to do this; I think the keywords will help with the searches, however. --> MPHO type: Organs/Multiple types or not specified (EP)
Expert comments for publication:
General topic review. Guidelines of UNOS/DTAC (2011) and UK Guidelines (2011) are listed along with specific discussions of melanoma, choriocarcinoma, CNS tumors, renal cell carcinoma, prostate cancer, ureteral carcinoma, endometrial cancer, breast cancer, lung cancer, and hematologic malignancies. Brief reference to hepatobiliary malignancies, pancreatic adenocarcinoma and colorectal carcinoma are made. 60 references are listed with donor cancer transmission references ranging from years 1990-2012. Discussions follow general guidelines, although positions on the use of donors with ureteral cancer are controversial.