Graft failure - uterus transplantation

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
2/9 of the cases described here
Time to detection: 
3 days - 3.5 months
Alerting signals, symptoms, evidence of occurrence: 
Hysterectomy had to be performed in 2 patients (out of 9). One uterus was removed after 3 days because of bilateral thrombosis of the uterine vessels. The other uterus was removed 3.5 months after surgery because of intrauterine infection, that developed into an abscess and septicemia.
Demonstration of imputability or root cause: 
Postoperative complication (direct result of the operation)
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest references: 
1) Mats Brännström. Uterus transplantation and beyond. J Mater Sci: Mater Med (2017) 28:70 2) Brännström M, Dahm Kähler P, et al. Uterus transplantation: A Rapidly Expanding Field. Transplantation. 2017 Nov 28.
TO ADD: Organs-> Composite tissues grafts -> Uterus - ok
Expert comments for publication: 
The initial 11 human uterus transplantation (UTx) attempts and their outcomes published in the scientific literature are described in detail in this paper (review period 2000-2013). A future extension of UTx, i.e. the creation of a bioengineered uterus, is also commented. New clinical trials in order to accumulate data to further optimize the procedure in relation to safety and efficiency are needed. In this regard, the creation of a global registry to follow donors, recipients and children born after UTx is central.