Macroscopic (frank) haematuria due to IgA nephropathy

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Time to detection: 
Occurs during GCSF injections (although has been described to occur several days later in at least one case).
Alerting signals, symptoms, evidence of occurrence: 
Demonstration of imputability or root cause: 
Renal biopsy. Definite imputability (if biopsy-proven).
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest references: 
1) Lee JB, Billen A, et al. Exacerbation of IgA nephropathy following G-CSF administration for PBSC collection: suggestions for better donor screeningBone Marrow Transplant. 2016 Feb;51(2):286-7. 2) Funakoshi, Y, Nazneen A, et al. Possible involvement of G-CSF in IgA nephropathy developing in an allogeneic peripheral blood SCT donor. Bone Marrow Transplant, 2010, Volume 45, Issue 9, p.1477 - 1478
The WMDA annual report 2015 should be added to record 501(Bronwen)
Expert comments for publication: 
Uncommon although documented causal link of haematuria provoked by GCSF injection due to underlying IgA nephropathy.