(Subject review): Donor transmitted and de novo cancer after liver transplantation (2014)

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
N/A: Subject review of a published reports of a variety of cancers transmitted by liver transplantation up to January 2014.
Time to detection: 
Alerting signals, symptoms, evidence of occurrence: 
Demonstration of imputability or root cause: 
Imputability grade: 
Not Assessable
Groups audience: 
Suggest new keywords: 
Subject review
large bowel adenocarcinoma
colon adenocarcinoma
astrocytoma/gliolastoma multiforme
astrocytomas and glioblastomas not further specified
Kaposi's sarcoma
lymphoma, type not specified
neuroendocrine carcinoma
Ovarian/fallopian tumor, other or type not specified
Pancreas cancer/other or type not specified
Sarcoma/other or type not specified
carcinoma of unknown primary site
urothelial (transitional) cell carcinoma
liver transplant
Suggest references: 
Desai R, Neuberger J. Donor transmitted and de novo cancer after liver transplantation. World J Gastroenterol. 2014 May 28;20(20):6170–9.
First edit done MN. Second edit done KL. Second reviewer changed tumor from choriocarcinoma to liver. Please confirm. MN: Actually, I believe that since liver is the transplant organ but there are no cases of liver cancer, we should not use liver cancer as a search item. We would need to clone the record, which would result in at least 14 clones. I will defer this to Evi and Mike as to how they would like to deal with this. The choice of choriocarcinoma was arbitrary, I was just picking one of the mentioned tumors. If the user searched by tumor, they would get this record once. But if they searched using the dropdown box for liver transplant, it would show up 14 times. Could be solved by recommending keyword search with instructions as a popup on the page, for example.
Expert comments for publication: 
The authors include 30 cases of previously reported donor tumors transmitted by liver transplantation in their review. These include choriocarcinoma (5), colon adenocarcinoma (3), CNS tumors (astrocytoma 1, glioblastoma 2, malignant glioma 1, pinealoblastoma 1), Kaposi sarcoma (1), lymphoma (1), melanoma (5), neuroendocrine cancer (3), urothelial carcinoma (2), ovarian, pancreatic or unspecified adenocarcinoma (1 each), sarcoma (1) squamous cell carcinoma (1). In all cases in which information is available (except for the 5 CNS tumors) the presence of tumor was not suspected prior to transplant. In 17 of those cases the cause of donor death was a cerebrovascular bleed or cerebrovascular event. There is also a synopsis of the UNOS/DTAC and Council of Europe guidelines and suggestions for recipient management.