Status:
Ready to upload
Record number:
1773
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Rare
Time to detection:
Severe anaphylactic reaction within several minutes after intrauterine insemination.
Alerting signals, symptoms, evidence of occurrence:
Generalized pruritus, abnominal pain, nausea and vomiting followed by bronchospasm and urticaria.
Demonstration of imputability or root cause:
Skin prick tests were performed for several allergens, resulting positive to bovine serum albumin (BSA). Moreover, high serum levels of IgE antibody against BSA have been found. These data showed that BSA, contained in sperm culture medium, was the factor which triggered the anaphylactic reaction.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
References:
Suggest new keywords:
anaphilactic reaction, sperm medium, intrauterine insemination, IUI, bovine serum albumin, BSA, human serum albumin, HSA
Reference attachment:
Suggest references:
1) Orta M et al. Anaphylactic reaction after artificial insemination. Ann Allergy Asthma Immunol. 2003 Apr;90(4):446-51.
2) Pagán JA(1), Postigo I, Rodríguez-Pacheco JR, Peña M, Guisantes JA, Martínez J. Bovine serum albumin contained in culture medium used in artificial insemination is an important anaphylaxis risk factor. Fertil Steril. 2008 Nov;90(5):2013.e17-9.
3) Sonenthal K, McKnight T, Shaughnessy M, et al. Anaphylaxis during intrauterine insemination secondary to bovine serum albumin. Fertil Steril 1991;56:1188–1191.
4) de Blay F, Tomb R, Vouillot C, et al. Urticaria and angioedema during insemination with fluid containing bovine serum albumin. Contact Dermatitis 1993;28:119.
5) Wuthrich B, Stern A, Johansson SG. Severe anaphylactic reaction to bovine serum albumin at the first attempt of artificial insemination. Allergy 1995;50:179–183.
6) Matheu V, Caloto M, De Barrio M, et al. Life-threatening anaphylaxis after artificial insemination. Lancet 2002;359:1779.
Expert comments for publication:
Six cases of allergic reaction due to BSA after insemination have been described. Nowadays, the sperm culture medium with BSA is no longer used and human serum albumin (HSA) has replaced BSA.