Antibody formation (red blood cell alloantibodies)

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Common. About 8% of first time RBC transfused patients will form a red cell alloantibody. This randomized prospective trial compares antibody formation rate of standard vs extended serologic matching, observing about 2/3 reduction in antibody formation rate with extended panel matched RBC transfusion, but only in patients not receiving platelets.
Time to detection: 
Delayed over months following the transfusion.
Alerting signals, symptoms, evidence of occurrence: 
Delayed serologic reactions, presence of a newly formed alloantibody
Demonstration of imputability or root cause: 
RBC alloantibodies being formed to discordant antigens (antigens on red cells not present in the recipient)
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
RBC alloantibody formation, extended serologic matching
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Expert comments for publication: 
Study demonstrates that extended matching of RBCs, beyond ABO-D in patients not also receiving platelets, can reduce the development of RBC alloantibodies.