Plasma exchange complications in patients treated for TTP (Review Article)

Status: 
Ready to upload
Record number: 
1756
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Major complications occurred in 17% of patients undergoing therapeutic plasma exchange (TPE) for thrombotic thrombocytopenic purpura (TTP). No fatalities, central venous catheter-related complications, sepsis attributed to central venous catheter, hematoma. Plasma-related complications include: respiratory distress, fluid overload. Minor complications in 34% of patients: urticaria, dyspnea responding to nasal cannula oxygen, hypotension responding to fluid administration.
Time to detection: 
Not stated
Alerting signals, symptoms, evidence of occurrence: 
Clinical observation by nurses performing TPE procedures: additional hospitalization or transfer to ICU, additional invasive procedure, new systemic treatment, red blood cell transfusion, TPE stopped.
Demonstration of imputability or root cause: 
Clinical observation
Imputability grade: 
2 Probable
Groups audience: 
Suggest new keywords: 
therapeutic plasma exchange
Reference attachment: 
Suggest references: 
Som S, et al. Decreasing frequency of plasma exchange complications in patients treated for thrombotic thrombocytopenic purpura-hemolytic uremic syndrome, 1996 to 2011. Transfusion 2012; 52: 2525-32
Expert comments for publication: 
Frequency of TPE-related major complications is trending lower, possibly related to more specific TTP treatment (corticosteroids and rituximab) and shorter duration of treatment required to achieve remission.