Status:
Ready to upload
Record number:
1745
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
In this Commentary, the estimated incidence of anaphylactic reactions following RBC transfusion estimated at 1 per 50,000. Evidence against a causative role for anti-IgA is the thesis of this publication---American Red Cross National Reference Laboratory data: only 17% of recipients with IgA deficiency have anti IgA; Canadian Blood Services data: no cases with absent IgA or anti-IgA among 43 cases of transfusion-related anaphylactic reactions.
Time to detection:
N/A
Alerting signals, symptoms, evidence of occurrence:
Severe allergic reaction with respiratory involvement (i.e., wheezing, dyspnea) including 11 fatalities. Only 17% found to be IgA deficient (IgA deficiency defined as <0.05 mg/dL).
Demonstration of imputability or root cause:
This Commentary questions the validity of the entity IgA deficiency associated anaphylaxis.
Groups audience:
Keywords:
References:
Reference attachment:
Suggest references:
The entity of immunoglobulin A–related anaphylactic transfusions reaction is not evidence based. Sandler SG et al. Transfusion. 2015 Jan;55(1):199-204
Note:
Interest for those concerned about pathogenesis of anaphylactic reactions.. Provides some evidence about choice of blood products for those suffering anaphylactic reactions requiring further transfusions.
Expert comments for publication:
Commentary providing information about an infrequent transfusion associated adverse event. The publication posts that anaphylactic reactions are unlikely related to IgA deficiency. This is an important concept.