Immunoglobulin A–related anaphylactic transfusions reactions

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
In this Commentary, the estimated incidence of anaphylactic reactions following RBC transfusion estimated at 1 per 50,000. Evidence against a causative role for anti-IgA is the thesis of this publication---American Red Cross National Reference Laboratory data: only 17% of recipients with IgA deficiency have anti IgA; Canadian Blood Services data: no cases with absent IgA or anti-IgA among 43 cases of transfusion-related anaphylactic reactions.
Time to detection: 
Alerting signals, symptoms, evidence of occurrence: 
Severe allergic reaction with respiratory involvement (i.e., wheezing, dyspnea) including 11 fatalities. Only 17% found to be IgA deficient (IgA deficiency defined as <0.05 mg/dL).
Demonstration of imputability or root cause: 
This Commentary questions the validity of the entity IgA deficiency associated anaphylaxis.
Groups audience: 
Suggest references: 
The entity of immunoglobulin A–related anaphylactic transfusions reaction is not evidence based. Sandler SG et al. Transfusion. 2015 Jan;55(1):199-204
Interest for those concerned about pathogenesis of anaphylactic reactions.. Provides some evidence about choice of blood products for those suffering anaphylactic reactions requiring further transfusions.
Expert comments for publication: 
Commentary providing information about an infrequent transfusion associated adverse event. The publication posts that anaphylactic reactions are unlikely related to IgA deficiency. This is an important concept.