Hepatitis C Virus (HCV)

Ready to upload
Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Since the introduction of NAT techniques as the screening method for HCV infection for blood products, the chance of a transmission form donor to recipient is almost none. It is estimated a rate of 1-2 HCV infection per million blood donation in developing countries that once detected preclude transmission form donor to recipient.
Time to detection: 
With the use of NAT techniques or the detection of HCV Ag in case of not having access to NAT, the window period form infection to detection is about 7 days.
Alerting signals, symptoms, evidence of occurrence: 
Unfortunately there are no clinical signs or symptoms to detect acute HCV infection. The way to suspect infection is by altered blood analysis or asking for risk factors
Demonstration of imputability or root cause: 
There is probability instead of certainty due to the impossibility for sequencing HCV virus in both donor and recipient. However, the transmission from the donor is consistent for two of the recipients infected within the same period of time.
Imputability grade: 
2 Probable
Suggest new keywords: 
HCV infection
Blood products
platelet transfusion
Reference attachment: 
Suggest references: 
Probable hepatitis C virus transmission from a seronegative blood donor via cellular blood products. Biceroglu SU et al. Blood Transfus.. 12 Suppl 1:s69-70, 2014 Jan.
MG: This should please be merged with record 1839.
Expert comments for publication: 
This article supports the fact that HCV infection in donors must be screened via NAT techniques in addition to anti-HCV or, in its absence, with HCV Ag.