Status:
Ready to upload
Record number:
1686
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
First case of acute rejection of a cryopreserved arterial homograft (CAH) published in the literature (2015)
Time to detection:
1 month
Alerting signals, symptoms, evidence of occurrence:
A 52-year-old male underwent a right femoropopliteal bypass (FPB) with a cryopreserved femoral artery to treat a thrombosis of a previous FPB performed 9 months earlier with a saphenous vein graft. This venous graft was used to treat an infection of a prosthetic graft, and was removed during a third procedure. The patient was referred to the hospital 1 month later because of the palpation of a beating femoral mass.
Demonstration of imputability or root cause:
CT scan showed multiple pseudoaneurysms of the FPB over its entire length. Results of the CT were confirmed at macroscopic inspection after
explantation and by histology. The donor characteristics were normal and the tissue has been processed according to protocol.
Imputability grade:
2 Probable
Groups audience:
Keywords:
Reference attachment:
Suggest references:
Soquet J., Chambon JP., Goffin Y., Jashari R. (2015) Acute rejection of cryopreserved arterial homograft. Cell Tissue Bank 16(3):331-3
Expert comments for publication:
The European Homograft bank has been distributing vascular allografts without ABO/HLA typing for donor and recipient since 1991. To the author's opinion, this is the first well documented case of acute rejection of a cryopreserved arterial homograft. The question of the immunogenicity of cryopreserved homografts is raised.