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Record number:
1680
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
In this report 3,802 blastocysts were analyzed by means of array-comparative genomic hybridization testing; 181 (4,8%) were mosaic embryos. Eighteen women didn't have euploid embryos but only a mosaic embryo each. Eight (44,4 %) resulted in clinical pregnancy, of which six resulted in the birth of a singleton infant at term.
Alerting signals, symptoms, evidence of occurrence:
All pregnancies that went to term were confirmed to have a normal karyotype at time of chorionic villus sampling (usually between weeks 10 - 13 of pregnancy). These pregnancies resulted in healthy euploid newborns.
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Keywords:
Reference attachment:
Suggest references:
Healthy Babies after Intrauterine Transfer of Mosaic Aneuploid Blastocysts. Ermanno Greco, M.D. Maria Giulia Minasi, M.Sc.Francesco Fiorentino, Ph.D. N Engl J Med 2015; 373:2089-2090November 19, 2015DOI: 10.1056/NEJMc1500421
Expert comments for publication:
Mosaic embryos, a relatively common finding in IVF-embryos, are characterized by the presence of a mixture of diploid and aneuploid cell lines. Preimplantation genetic screening is used to identify chromosomally normal (euploid) embryos and select them for intrauterine transfer in order to improve the clinical outcome of IVF. Mosaic embryos are not usually transferred because they are deemed to be abnormal, but the effect of mosaicism on implantation and the developmental potential of these embryos is not known. This report demonstrates that some mosaic embryos can develop in healthy babies and that some healthy babies would be lost if all mosaic embryos are not transferred.