Status:
Ready to upload
Record number:
1672
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment for Lung Cancer (Council of Europe, 2022): Any histotype of newly-diagnosed lung cancer is an unacceptable risk for organ donation. Lung cancer in the donor history: Treated lung cancer is considered to be associated with a high transmission risk. Risk may decrease after curative therapy, with recurrence-free time and with increasing probability of cure.
Time to detection:
16 months
Alerting signals, symptoms, evidence of occurrence:
Mass in the graft area, fever and chills. The patient was diagnosed with an abscess in the area of the grafted kidney and had an associated urinary fistula, leading to the decision to remove the graft. The patient died 7 days after the intervention as a result of disseminated cryptococcosis.
Demonstration of imputability or root cause:
The donor had been diagnosed with a poorly differentiated epidermoid carcinoma of the lung at the time of death. At autopsy, a metastasic nodule was identified in the contralateral (non grafted) kidney. The explanted graft contained a tumour that shared histologic features with the donor´s poorly differentiated epidermoid (squamous cell) carcinoma.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest new keywords:
transplantectomy
Lung cancer
Bronchogenic
Squamous cell carcinoma
Reference attachment:
Suggest references:
Lanari,A., Rodo, J.B., Barcat.J.A., Molins, M., Gallo Morando, G., Torres Agüero, M., Lopez Balnco, O.(1968).Desarrollo de un cancer del dador en el riñón injertado. Medicina XXVII (4):165-170
Expert comments for publication:
This is an older report (published in 1968), when limited experience existed regarding malignancy transmission and more sophisticated tools for assessing/documenting imputability were not available.