Idiopathic pneumonia syndrome and platelet transfusion

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
75 of 906 patients (8%) undergoing allogeneic HCT developed idiopathic pneumonia syndrome.
Time to detection: 
23 days (median)
Alerting signals, symptoms, evidence of occurrence: 
Retrospective cohort study criteria for idiopathic pneumonia syndrome: clinical, radiographic, microbiology, and pathology data.
Demonstration of imputability or root cause: 
Correlation of platelet transfusions from apheresis collections or pooled platelet rich plasma collections. No difference in IPS occurrence, HR= 1.36 for both.
Imputability grade: 
1 Possible
Groups audience: 
Reference attachment: 
Suggest references: 
Vande Vusse, L.K., Madtes, D.K., Bolgiano, D. and Watkins, T.R. (2015). The association between platelet transfusion and idiopathic pneumonia syndrome is unaffected by platelet product type. Transfusion, 2015, doi:10.1111/trf.13361
Expert comments for publication: 
Report provides statistical association between platelet transfusion only. No attempt to demonstrate causation provided.