Pulmonary complication induced by donor lymphocte infusion (DLI)

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Case report
Time to detection: 
8 weeks
Alerting signals, symptoms, evidence of occurrence: 
A 55-year-old woman with acute myeloid leukemia received donor lymphocte infusion (DLI) for conversion from recipient predominant to complete donor chimerism on day 1193 after allogeneic HSCT. Eight weeks later, she complained of dyspnea with fever; chest computed tomography revealed diffuse, bilateral, ground glass opacity and reticular appearance. She was diagnosed as having NIPC (non-infectious pulmonary complication) based on serum and bronchoalveolar lavage (BAL) findings. She was successfully treated with prednisolone and completely recovered.
Demonstration of imputability or root cause: 
Clinical course and laboratory findings including cells not derived from donor T-cells in BAL.
Imputability grade: 
2 Probable
Groups audience: 
Suggest new keywords: 
donor lymphocyte infusion (DLI), dyspnea, fever; chest computed tomography, bronchoalveolar lavage fluid (BALF), hematopoietic stem cells (HPC),
Suggest references: 
Nishie, M., Fujii, N., Mimura, Y., Asano, T., Mimura-Kimura, Y., Aoe, K., Aoe, M., Nakashima, H., Fujiwara, H., Nishimori, H., Matsuoka, K. I., Kondo, E., Maeda, Y. and Tanimoto, M. (2015). Vigorous inflammatory responses in noninfectious pulmonary complication induced by donor lymphocyte infusion. Transfusion. 2015 Oct 9. doi: 10.1111/trf.13283.