Status:
Ready to upload
Record number:
1661
Adverse Occurrence type:
MPHO Type:
Time to detection:
35 - 46 days
Alerting signals, symptoms, evidence of occurrence:
This 2004 report describes a patient who had open heart surgery and required 23 units of blood components, 14 FFP, 8 RBC, and 1 PLT unit. The patient had demonstrable HEV seroconvertion 35 days post transfusion and developed acute hepatitis on day 46, with an elevated ALT level of 1595 IU/L and AST level of 1727 IU / L; these normalized within 1 month. Trace back exercise revealed a donor of FFP who was viraemic with HEV genotype 3 at the time of donation, with no detectable IgG or IgM and normal transaminases.
Demonstration of imputability or root cause:
Imputability demonstrated by sequencing of ORF 2
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest references:
Transfusion-transmitted hepatitis E caused by apparently indigenous hepatitis E virus strain in Hokkaido, Japan., Matsubayashi, Keiji, Nagaoka Yasuhiro, Sakata Hidekatsu, Sato Shinichiro, Fukai Kanji, Kato Toshiaki, Takahashi Kazuaki, Mishiro Shunji, Imai Mitsunobu, Takeda Naokazu, et al. , //Transfusion, 2004, Volume 44, Issue 6, Copyright (C) 2004 Blackwell Publishing Ltd., p.934 - 940, (2004) Google Scholar
Transfusion-transmitted hepatitis E caused by apparently indigenous hepatitis E virus strain in Hokkaido, Japan., Matsubayashi, Keiji, Nagaoka Yasuhiro, Sakata Hidekatsu, Sato Shinichiro, Fukai Kanji, Kato Toshiaki, Takahashi Kazuaki, Mishiro Shunji, Imai Mitsunobu, Takeda Naokazu, et al. , //Transfusion, 2004, Volume 44, Issue 6, Copyright (C) 2004 Blackwell Publishing Ltd., p.934 - 940, (2004)