Peripheral Blood Stem Cell (PBSC) infusion-related febrile reaction (IRFR)

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Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
A retrospective analysis of 490 patients received allogeneic stem cell transplantation (SCT) between October 2009 and December 2011 were analysed for infusion-related febrile reactions (IRFR).
Time to detection: 
Retrospective analysis
Alerting signals, symptoms, evidence of occurrence: 
Infusion-related febrile reactions (IRFR) were defined as unexplained fever of more than 38 degrees C within 24 hours after the infusion of PBSCs. Eighty-eight patients (30.7%) of 287 cases after the infusion of haploidentical PBSCs were diagnosed as IRFRs, chills in 3.5% (10/88), diarrhea in 21.6% (19/88), an erythematous skin rash in 0.3% (1/88), hypoxemia in 1.0% (3/88), and no other accompanying symptoms in 62.5% (55/88). Significantly higher elevation of C-reactive protein and complement C3 was seen in the IRFR group compared with the non-IRFR group.
Demonstration of imputability or root cause: 
Multivariate analysis showed higher CD34+ dose was a significant predictor for IRFR (p = 0.023; hazard ratio = 1.848; 95% confidence interval, 1.087-3.142). No IRFRs were observed in patients undergoing HLA-identical sibling and unrelated transfusions.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
infusion related febrile reaction, IRFR, chills, diarrhea, erythematous skin rash, hypoxemia, PBSC, complement C3, C-reactive protein
Reference attachment: 
Suggest references: 
Chen, Y., Huang, X. J., Wang, Y., Liu, K. Y., Chen, H., Chen, Y. H., Zhang, X. H., Wang, F. R., Han, W., Wang, J. Z., Yan, C. H., Zhang, Y. Y., Sun, Y. Q. and Xu, L. P. (2015). Febrile reaction associated with the infusion of haploidentical peripheral blood stem cells: incidence, clinical features, and risk factors. Transfusion 55(8):2023-2031.