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Adverse Occurrence type:
A retrospective analysis of 490 patients received allogeneic stem cell transplantation (SCT) between October 2009 and December 2011 were analysed for infusion-related febrile reactions (IRFR).
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
Infusion-related febrile reactions (IRFR) were defined as unexplained fever of more than 38 degrees C within 24 hours after the infusion of PBSCs. Eighty-eight patients (30.7%) of 287 cases after the infusion of haploidentical PBSCs were diagnosed as IRFRs, chills in 3.5% (10/88), diarrhea in 21.6% (19/88), an erythematous skin rash in 0.3% (1/88), hypoxemia in 1.0% (3/88), and no other accompanying symptoms in 62.5% (55/88). Significantly higher elevation of C-reactive protein and complement C3 was seen in the IRFR group compared with the non-IRFR group.
Demonstration of imputability or root cause:
Multivariate analysis showed higher CD34+ dose was a significant predictor for IRFR (p = 0.023; hazard ratio = 1.848; 95% confidence interval, 1.087-3.142). No IRFRs were observed in patients undergoing HLA-identical sibling and unrelated transfusions.
Suggest new keywords:
infusion related febrile reaction, IRFR, chills, diarrhea, erythematous skin rash, hypoxemia, PBSC, complement C3, C-reactive protein
Chen, Y., Huang, X. J., Wang, Y., Liu, K. Y., Chen, H., Chen, Y. H., Zhang, X. H., Wang, F. R., Han, W., Wang, J. Z., Yan, C. H., Zhang, Y. Y., Sun, Y. Q. and Xu, L. P. (2015). Febrile reaction associated with the infusion of haploidentical peripheral blood stem cells: incidence, clinical features, and risk factors. Transfusion 55(8):2023-2031.