Delayed Hemolytic Transfusion Reaction (DHTR), anti-Ce+e

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
4 days
Alerting signals, symptoms, evidence of occurrence: 
Back pain, fever, and hemoglobinuria occurred 4 days after receiving 2 incompatible units. Hemoglobinuria persisted for 5 days preceded by oliguria and a rising blood urea nitrogen (BUN), creatinine and bilirubin.
Demonstration of imputability or root cause: 
An anti-Ce+e was detected retrospectively, pre-transfusion, and easily detected post transfusion.
Imputability grade: 
2 Probable
Groups audience: 
Reference attachment: 
Suggest references: 
Molthan, L, Matulewicz, TJ, Bansal-Carver, B and Benz, EJ. (1984). An immediate hemolytic transfusion reaction due to anti-C and a delayed hemolytic transfusion reaction due to anti-Ce+e: hemoglobinemia, hemoglobinuria and transient impaired renal function. Vox Sang 47:348-53
Expert comments for publication: 
Rh (D) antibodies often have the capacity to cause severe immediate or delayed extravascular hemolytic transfusion reactions and all Rh antibodies should be considered to be potentially clinically significant. Rh antibodies include: D, C, C(w), E, c, e, e(8), Ce, f, Go(a), G, V (Rh 10), Rh17, Rh29, RH19.