Acute Hemolytic Transfusion Reaction (AHTR), anti-C

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Case report
Time to detection: 
2 hours - weeks
Alerting signals, symptoms, evidence of occurrence: 
Back pain, fever and hemoglobinuria in one case, only hemoglobinuria in another case.
Demonstration of imputability or root cause: 
Demonstration of antibody in the eluate and serum. In two cases there was increased creatinine, plasma hemoglobenemia. One case also demonstrated brown plasma with increased bilirubin.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
acute hemolytic reaction
anti-Ce, anti-f
Reference attachment: 
Suggest references: 
Molthan, L, Matulewicz, TJ, Bansal-Carver, B and Benz, EJ. (1984). An immediate hemolytic transfusion reaction due to anti-C and a delayed hemolytic transfusion reaction due to anti-Ce+e: hemoglobinemia, hemoglobinuria and transient impaired renal function. Vox Sang 47:348-53
Expert comments for publication: 
This is one of the early case reports about the diverse hemolytic reactions associated with anti-C. Two cases here demonstrated hemolgobinuria, one of which was acute while two other cases demonstrated no clinical symptoms. Rh antibodies often have the capacity to cause severe immediate or delayed extravascular hemolytic transfusion reactions and all Rh antibodies should be considered to be potentially clinically significant. Rh antibodies include: D, C, C(w), E, c, e, e(8), Ce, f, Go(a), G, V (Rh 10), Rh17, Rh29, RH19.