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Adverse Occurrence type:
Single case report
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
Three weeks after first transfusion the patient developed anemia and hyperhemolysis.
Demonstration of imputability or root cause:
Complement positive (C3d) but IgG negative serologic evaluation
Suggest new keywords:
DHTR (delayed hemolytic transfusion reaction)
Hannema SE, Brand A, van Meurs A, Smiers FJ. (2010). Delayed hemolytic transfusion reaction with hyperhemolysis after first red blood cell transfusion in child with beta-thalassemia: challenges in treatment. Transfusion 50:429-32
Ready to upload once the taxonomy is sorted: Harm to a recipient/Immunological complications/Delayed Hemolytic Reaction (Evi)
Expert comments for publication:
Exceptionally severe case that persisted through two bone marrow transplants and refractory to standard autoimmune therapies.