Delayed Hemolytic Transfusion Reaction (DHTR) with hyperhemolysis in a child with Beta-thalassemia

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Single case report
Time to detection: 
3 weeks
Alerting signals, symptoms, evidence of occurrence: 
Three weeks after first transfusion the patient developed anemia and hyperhemolysis.
Demonstration of imputability or root cause: 
Complement positive (C3d) but IgG negative serologic evaluation
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
DHTR (delayed hemolytic transfusion reaction)
beta thalassemia
Suggest references: 
Hannema SE, Brand A, van Meurs A, Smiers FJ. (2010). Delayed hemolytic transfusion reaction with hyperhemolysis after first red blood cell transfusion in child with beta-thalassemia: challenges in treatment. Transfusion 50:429-32
Ready to upload once the taxonomy is sorted: Harm to a recipient/Immunological complications/Delayed Hemolytic Reaction (Evi)
Expert comments for publication: 
Exceptionally severe case that persisted through two bone marrow transplants and refractory to standard autoimmune therapies.