Anaphylaxis from platelets by passive transfer of peanut allergen

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Case report
Time to detection: 
Alerting signals, symptoms, evidence of occurrence: 
Rash, angioedema, hypotension, dyspnea. Resolved within 30 minutes of receiving epinephrine.
Demonstration of imputability or root cause: 
Three of 5 blood donors ingested peanuts prior to donation. Recipient had history of similar reaction after eating peanuts and had IgE antibodies reactive to Ara h2. Digestion resistant peanut peptide Ara h2 can be detected in serum for up to 24 hours post-peanut ingestion.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
anaphylactic transfusion reaction
peanut allergy
Suggest references: 
Jacobs JF, Baumert JL, Brons PP, Joosten I, Koppelman SJ, van Pampus EC. (2011). Anaphylaxis from passive transfer of peanut allergen in a blood product. N Engl J Med 364:1981-2