Hyperhemolysis syndrome in sickle cell anemia

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Three case reports. Frequency data not provided.
Time to detection: 
Within 7 days of transfusion.
Alerting signals, symptoms, evidence of occurrence: 
Pain, fever, reticulocytopenia, laboratory evidence of hemolysis, worsening anemia, and relapse of hyperhemolysis syndrome after additional red blood cell transfusions.
Demonstration of imputability or root cause: 
Case reports. Certain.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
innocent bystander hemolysis
sickle cell anemia
Reference attachment: 
Suggest references: 
Santos B, Portugal R, Nogueira C, Loureiro M. (2015). Hyperhemolysis syndrome in patients with sickle cell anemia: report of three cases. Transfusion doi:10.1111/trf.12993
Expert comments for publication: 
Interesting case reports