Acute Hemolytic Transfusion Reaction (AHTR), anti-P antibodies

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
within 24 hours
Alerting signals, symptoms, evidence of occurrence: 
Clinical or laboratory features of hemolysis are present. Common signs of AHTR are: fever, chills/rigors, facial flushing, chest pain, abdominal pain, back/flank pain,nausea/vomiting,diarrhea, hypotension, pallor, jaundice, oligoanuria, diffuse bleeding, dark urine. Common laboratory features are: hemoglobinemia, hemoglobinuria, decreased serum haptoglobin, unconjugated hyperbilirubinemia, Increased LDH an AST levels, decreased hemoglobin levels. Not all clinical or laboratory features are present in cases of AHTR. P antibodies include: P, P +P(1)+P(k), anti-Tj(a) and P1.
Demonstration of imputability or root cause: 
Clinical or laboratory features of hemolysis are present along with serological evidence for the presence of the antibody including elution of antibody from red cells.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
P, P +P(1)+P(k), anti-Tj(a), P1, LKE
Reference attachment: 
Suggest references: 
Poole, J and Daniels G. (2007). Blood group antibodies and their significance in transfusion medicine. Transfus Med Rev 21(1): 58-71.
Expert comments for publication: 
Anti-P and -PP1Pk are naturally occurring antibodies invariably present in individuals with the very rare Pk and p phenotypes. LKE is related to the P antigens and is a high incidence antigen.