Acute Hemolytic Transfusion Reaction (AHTR), anti-Kidd antibodies

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
within 24 hours
Alerting signals, symptoms, evidence of occurrence: 
Clinical or laboratory features of hemolysis are present. Common signs of AHTR are: fever, chills/rigors, facial flushing, chest pain, abdominal pain, back/flank pain,nausea/vomiting,diarrhea, hypotension, pallor, jaundice, oligoanuria, diffuse bleeding, dark urine. Common laboratory features are: hemoglobinemia, hemoglobinuria, decreased serum haptoglobin, unconjugated hyperbilirubinemia, Increased LDH an AST levels, decreased hemoglobin levels. Not all clinical or laboratory features are present in cases of AHTR.
Demonstration of imputability or root cause: 
Clinical or laboratory features of hemolysis are present along with serological evidence for red cell antibodies including elution of antibodies from the patient's red cells. Anti-Kidd antibodies include: Jk(a) - Jk1, Jk(b) - Jk2, Jk3.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
Jk(a) - Jk1, Jk(b) - Jk2, Jk3
Reference attachment: 
Suggest references: 
Poole, J. and Daniels, G. (2007). Blood group antibodies and their significance in transfusion medicine. Transfus Med Rev 21(1):58-71.
Expert comments for publication: 
Kidd antibodies, anti-Jka, -Jkb, and -Jk3, have been responsible for severe and fatal immediate and delayed reactions. The most commonly encountered immune antibodies are D > K> E> Fya> Jka.