Status:
Ready to upload
Record number:
1597
Adverse Occurrence type:
MPHO Type:
Time to detection:
within 24 hours
Alerting signals, symptoms, evidence of occurrence:
Common signs of AHTR are: fever, chills/rigors, facial flushing, chest pain, abdominal pain, back/flank pain, nausea/vomiting, diarrhea, hypotension, pallor, jaundice, oligoanuria, diffuse bleeding, dark urine. Common laboratory features are: hemoglobinemia, hemoglobinuria, decreased serum haptoglobin, unconjugated hyperbilirubinemia, increased LDH and AST levels, decreased hemoglobin levels. Rh antibodies include: D, C, C(w), E, c, e, e(8), Ce, f, Go(a), G, V (Rh 10), Rh17, Rh29, RH19, hr(s), hr(B). Not all clinical or laboratory features are present in cases of AHTR.
Demonstration of imputability or root cause:
Clinical or laboratory features of hemolysis are present along with serological evidence for the presence of the antibody including elution of antibody from red cells.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest new keywords:
RH (D), C, C(w), E, c, e, e(8), Ce, f, Go(a), G, V (Rh 10), Rh17, Rh29, RH19, hr(s), hr(B), acute hemolytic transfusion reaction (AHTR), pallor, Oligoanuria, dark urine, haptoglobin, AST, LDH
Rh (Rhesus) antibodies, acute hemolysis, fever, chills, chest pain, abdominal pain, back pain, nausea, vomiting, diarrhea, hypotension, jaundice, bleeding, hemoglobinemia, hemoglobinuria, hyperbilirubinemia
Reference attachment:
Suggest references:
Poole, J and Daniels G. (2007). Blood group antibodies and their significance in transfusion medicine. Transfus Med Rev 21(1): 58-71.
Expert comments for publication:
Rh (D) antibodies often have the capacity to cause severe immediate or delayed extravascular hemolytic transfusion reactions and all Rh antibodies should be considered to be potentially clinically significant. The most commonly encountered immune antibodies are D > K> E> Fya> Jka.