Rh(D) alloimmunization in HSCs recipients from Rh(D) positve platelets

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
3.8 - 4.2 %
Time to detection: 
11 days - 10 months
Alerting signals, symptoms, evidence of occurrence: 
Clinical and transfusion records of patients who underwent hematopoietic stem cell transplantation from Rh (D) negative donors were reviewed. Forty seven patients with negative antibody screens were included, 29 who received autologous and 18 allogeneic HSCT and all received platelet transfusions during the process, the majority from pooled whole blood donations and 7% from single donor apheresis. Two autologous patients developed anti-D, one at 11 days (anti-D + anti-E) and the second patient at 10 months (anti-D).
Demonstration of imputability or root cause: 
Patients were tested before transplantation and had negative antibody screens but tested positive for Rh (D) at varying times after Rh (D) positive platelet transfusions.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest new keywords: 
whole blood platelets, Rh (D) antibody
transfusion reaction, allogeneic platelet transfusion, autologous stem cells, HSCs (hematopoietic stem cells), apheresis platelets, antibody positive
Reference attachment: 
Suggest references: 
Solves, P., Carpio, N., Gomez, I., Hernani, R., Sanz, G. F. and Sanz, M. A. (2015). Risk of RH (D) alloimmunisation after RH (D) positive platelet transfusions in patients undergoing haematopoietic stem cell transplantation. Transfus Med 25(1): 49-50; Cid, J., Carbasse, G., Pereira, A. et al. (2011) Platelet transfusions fromD+ donors to D−patients: a 10-year follow-up study of 1014 patients. Transfusion, 51, 1163–1169.