Case series: Donor(s) Renal cell, cervical carcinoma (without transmission) (1998)

Status:

Ready to upload

Record number:

1569

Adverse Occurrence type:

Donor disease without transmission

MPHO Type:

Liver

Estimated frequency:

N/A

Time to detection:

N/A: Tumors found in donors (1 cervical squamous cell carcinoma, one 2mm renal cell carcinoma, one 8mm renal cell carcinoma); no tumors in recipients

Alerting signals, symptoms, evidence of occurrence:

Cervical squamous cell carcinoma: found in donor at autopsy the day after transplant; allograft liver removed at day 7 and retransplant performed with second liver. No tumor at 7 years followup. 2 mm renal cell carcinoma: Liver split and given to two recipients; no intervention and recipients without tumor at 1 year followup. 8 mm renal cell carcinoma: Found in donor at time of liver transplant; transplant completed, no intervention; recipient died of GVHD at 7 months; no tumor found at recipient autopsy.

Demonstration of imputability or root cause:

N/A

Groups audience:

Malignancy

Keywords:

RCC (renal cell carcinoma)

liver transplantation

donor disease without documented transmission

References:

Management of recipients of hepatic allografts harvested from donors with malignancy diagnosed shortly after transplantation

Suggest new keywords:

transplantectomy

Cervical carcinoma

renal cell carcinoma

Reference attachment:

DetryClinTX1998[1].pdf

Suggest references:

Detry, O.; Honore, P.; Jacquet, N.; Meurisse, M. Management of recipients of hepatic allografts harvested from donors with malignancy diagnosed shortly after transplantation Clin Transplant 1998; 12 (6) :579 - 81