Status:
Ready to upload
Record number:
1555
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment for choriocarcinoma (Council of Europe, 2022):
Due to the high transmission and mortality rates, it is considered an unacceptable risk for organ donation in any stage of disease. History of choriocarcinoma: Due to the reported high transmission and mortality rates, it is considered to be associated with a high or unacceptable risk for transmission through organ donation, depending on the recurrence-free period prior to donor death.
Time to detection:
N/A
Alerting signals, symptoms, evidence of occurrence:
Two organ recipients from the same donor had both metastasis of choriocarcinoma.
Demonstration of imputability or root cause:
A donor donated lung-heart block, liver and right kidney. Lung was found to have nodule during transplant. Post-op day 1 nodule biopy revealed metastasis of choriocarcinoma. Liver tranplant recipient died of metastasis of choriocarcinoma. Kidney transplant recipinet developed metastasis of choriocarcinoma. Graft removed.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest references:
Knoop, C.; Jacobovitz, D.; Antoine, M.; Francquen, P.; Yernault, J.C.; Estenne, M. Donor-transmitted tumors in lung allograft recipients: report on two cases Transplantation 1994; 57 (11) :1679 - 80