Status:
Ready to upload
Record number:
1554
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment for choriocarcinoma (Council of Europe, 2022):
Due to the high transmission and mortality rates, it is considered an unacceptable risk for organ donation in any stage of disease. History of choriocarcinoma: Due to the reported high transmission and mortality rates, it is considered to be associated with a high or unacceptable risk for transmission through organ donation, depending on the recurrence-free period prior to donor death.
Time to detection:
Not specified
Alerting signals, symptoms, evidence of occurrence:
Final pathologic interpretation of donor lung nodule on postoperative day 1 showed choriocarcinoma.
Demonstration of imputability or root cause:
A donor provided lung-heart block, liver and right kidney. Lung was found to have nodule during transplant. Frozen section benign but final reading after transplant showed choriocarcinoma. Kidney transplant recipient developed metastasis of choriocarcinoma. Graft removed, given chemotherapy and survived without recurrence at 4 year followup. Liver transplant recipient died of metastasis of choriocarcinoma, time not given. Lung recipient died of sepsis on day 33; at autopsy, no evidence of additional tumors found.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest new keywords:
chemotherapy
transplantectomy
hCG (human chorionic gonadotropin)
choriocarcinoma
Suggest references:
Knoop, C.; Jacobovitz, D.; Antoine, M.; Francquen, P.; Yernault, J.C.; Estenne, M. Donor-transmitted tumors in lung allograft recipients: report on two cases Transplantation 1994; 57 (11) :1679 - 80
Note:
Remove "abnormal blood counts, first generation, second generation" from keywords, as they are irrelevant. (ok - Evi)
Expert comments for publication:
Presence of choriocarcinoma in multiple recipients sufficient to establish cause and effect.