Status:
Ready to upload
Record number:
1551
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment for choriocarcinoma (Council of Europe, 2022):
Due to the high transmission and mortality rates, it is considered an unacceptable risk for organ donation in any stage of disease. History of choriocarcinoma: Due to the reported high transmission and mortality rates, it is considered to be associated with a high or unacceptable risk for transmission through organ donation, depending on the recurrence-free period prior to donor death.
Time to detection:
1 day
Alerting signals, symptoms, evidence of occurrence:
Autopsy performed 1 day after donation in a 30 yr. female donor showed widespread choriocarcinoma; cause of death cerebral haemorrhage
Kidney recipient was immediately nephrectomized + IS stopped (graft showed multiple foci of choriocarcinoma), HCG increased, chemotherapy (Actinomycin+VP16) was given -> after 2 yrs. Normal HCG, no metastasis, re-TX intended
Liver recipient: could not be retransplanted due to poor health; 2 doses Ledertextrate, passed away 39 days post-transplant; choriocarcinoma found in allograft liver at autopsy
Demonstration of imputability or root cause:
Choriocarcinoma found in both donor and in kidney and liver recipients.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest new keywords:
choriocarcinoma
chemotherapy
metastatic disease
transplantectomy
hCG (human chorionic gonadotropin)
Suggest references:
Detroz, B.; Detry, O.; D'Silva, M.; Pirenne, J.; Defraigne, J.O.; Meurisse, M.; Honore, P.; Jacquet, N. Organ transplantation with undetected donor neoplasm Transplant Proc 1991; 23 (5) :2657
Note:
Remove "chorion carcionoma" which is misspelled and not a word. Remove "abnormal blood counts, first generation, second generation" as keywords, makes no sense.(OK)
Expert comments for publication:
1991 reference; CNS hemorrhage in a young woman should prompt consideration of possible underlying causes.