Status:
Ready to upload
Record number:
1540
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Most recent risk assessment (Council of Europe, 2022): Oesophageal, gastric, pancreatic, liver and biliary cancers diagnosed during donor procurement : These tumours are classified as unacceptable risk. Oesophageal, gastric, pancreatic, liver and biliary cancers in the donor history: Treated tumours of these kinds in the donor history are classified as high risk due to their aggressive behaviour. Risk may decrease for early stages after curative therapy, with recurrence-free time > 5 years and with increasing probability of cure, especially in cases of long-term survivors
Time to detection:
3 years
Alerting signals, symptoms, evidence of occurrence:
The (17 year old) donor died of hepatocellular carcinoma with metastases. Recipient developed hematuria at 3 years; pyelography showed deformed calyx and several lung masses were also found.
Demonstration of imputability or root cause:
Biopsy of the explanted renal tumor revealed anaplastic carcinoma, similar to the hepatocellular carcinoma of the donor.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Suggest new keywords:
metastatic disease
Liver cancer
transplantectomy
Suggest references:
Matter, B.; Zukoski, C.F.; Killen, D.A.; Ginn, E. Transplanted carcinoma in an immunosuppressed patient Transplantation 1970; 9 (1) :71 - 4
Expert comments for publication:
Allograft nephrectomy performed and immunosuppression discontinued. Lung tumors resolved and no evidence of tumor found at subsequent patient autopsy (patient died postoperatively after third renal transplant). Case is of historical interest only, as donor had known metastatic carcinoma.