Status:
Ready to upload
Record number:
1532
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
The prevalence of iron deficiency (ID) in new female donors was 12.0% compared with 1.3% in males. ID in female WB-only donors was 26.4%, in male WB-only donors was 6.3%. The prevalence of ID in apheresis-only donors was 6.3% in females and 2.2% in males. ID was found to be especially prevalent in female, premenopausal, frequent WB donors.
Time to detection:
Not applicable
Alerting signals, symptoms, evidence of occurrence:
Iron deficiency, anemia
Demonstration of imputability or root cause:
Evidence of occurrence was based on laboratory values. Iron deficiency was defined as ferritin <15 ng/mL for both genders; anemia was defined as hemoglobin < 12 mg/dL for females or < 13 mg/dL for males. The sensitivity of anemia to detect iron deficiency was 12.3% and the specificity was 97.1%; using anemia to predict iron deficiency had only moderate predictive value.
Groups audience:
Suggest new keywords:
iron deficiency
blood donors
low ferritin
low hemoglobin
Reference attachment:
Suggest references:
Salvin, H.E., Sant-Rayn, P., Marks, D.C. and Speedy, J. (2014). Iron deficiency in blood donors: a national cross-sectional study. Transfusion 54(10): 2434-44.
Expert comments for publication:
The increased risk of iron deficiency with blood donation, especially in premenopausal female, WB donors, is established in this manuscript. However, the risk of harm or sequelae of iron deficiency is not discussed or definitively established.