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Adverse Occurrence type:
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
None specified. Usual signs and symptoms (ISBT definitions) include: numbness or tingling of lips, feelings of vibrations, numbness or tingling in the fingers, metallic taste, chills, shivering, lightheadedness, feeling of tightness, muscle twitching, rapid or slow pulse, shortness of breath. Symptoms may progress to carpopedal spasms and vomiting and in severe reactions, to generalized muscle contractions (tetany), shock, irregular pulse and cardiac arrest.
Demonstration of imputability or root cause:
Occurrence during collection.
Suggest new keywords:
automated red cell collections
Eder, A.F, Dy, B.A., Kennedy, J.M., Notari,IV, E.P., Strupp, A., Wissel, M.E., Reddy, R., Gibble, J., Haimowitz, M.D., Newman, B.H. Chambers, L.A. Hillyer, C.D. and Benjamin, R.J. (2008). The American Red Cross donor hemovigilance program: complications of blood donation reported in 2006. Transfusion 48(9): 1809-19.
Expert comments for publication:
This was a review of all adverse donor reactions occurring within a one year period in the American Red Cross. The denominator was the number of satisfactory (complete) and incomplete donations. Collections included 6,014,472 whole blood (WB), 49,594 apheresis platelets and 228,183 combinations of automated red cell collections. Overall rates of adverse events were WB: 348/10,000 collections; apheresis platelets: 577/10,000 collections and automated red cells: 538/10,000 collections. Major reactions as defined by outside medical care were for WB: 3.2/10,000; automated red cells: 2.9/10,000; this data was not provided for apheresis platelet collections. No latency period was provided but is assumed to be at the time of donation or shortly after. No alerting signals were provided in the paper but were consistent with the ISBT definitions