Status:
Ready to upload
Record number:
1514
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
0.001%
Time to detection:
immediate
Alerting signals, symptoms, evidence of occurrence:
Not specified. Usual signs and symptoms (ISBT definitions) include: itching and redness at the venipuncture site, the bandage site, or the entire skin disinfection area. There may be a raised rash or hives in the areas that may expand to cover a larger area of the arm. The reaction may occur soon after donation or in the hours to days post-donation.
Demonstration of imputability or root cause:
Occurred at the time or shortly after donation.
Imputability grade:
2 Probable
Groups audience:
Keywords:
References:
Suggest new keywords:
Allergic reaction, whole blood donation
Reference attachment:
Suggest references:
Eder, A.F, Dy, B.A., Kennedy, J.M., Notari,IV, E.P., Strupp, A., Wissel, M.E., Reddy, R., Gibble, J., Haimowitz, M.D., Newman, B.H. Chambers, L.A. Hillyer, C.D. and Benjamin, R.J. (2008). The American Red Cross donor hemovigilance program: complications of blood donation reported in 2006. Transfusion 48(9): 1809-19.
Expert comments for publication:
This was a review of all adverse donor reactions occurring within a one year period in the American Red Cross. The denominator was the number of satisfactory (complete) and incomplete donations. Collections included 6,014,472 whole blood (WB), 49,594 apheresis platelets and 228,183 combinations of automated red cell collections. Overall rates of adverse events were WB: 348/10,000 collections; apheresis platelets: 577/10,000 collections and automated red cells: 538/10,000 collections. Major reactions as defined by outside medical care were for WB: 3.2/10,000; automated red cells: 2.9/10,000; this data was not provided for apheresis platelet collections.
No latency period was provided but is assumed to be at the time of donation or shortly after. No alerting signals were provided in the paper but were consistent with the ISBT definitions.