Malignant Hyperthermia

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Time to detection: 
1 day
Alerting signals, symptoms, evidence of occurrence: 
Dark urine, renal failure, myalgia, elevated liver enzymes, CK and myoglobin, rhabdomyolysis, dyspnea, pulmonary edema.
Demonstration of imputability or root cause: 
Known association with anaesthetic agents.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Suggest references: 
Hosoya N, Miyagawa K, Mimura T, et al. Malignant hyperthermia induced by general anesthesia for bone marrow harvesting. Bone Marrow Transplant. 1997 Mar;19(5):509-11