Transfer of Selecive IgA Deficiency to a bone marrow recipient

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Time to detection: 
3 months
Alerting signals, symptoms, evidence of occurrence: 
Relative lack of specific IgG2 anticarbohydrate antibodies in the donor and the recipient after transplant. IgG2 deficiency is considered as a prognostic marker for permanent lack of IgA.
Demonstration of imputability or root cause: 
Bone marrow transplant from HLA matched sibling with selective IgA deficiency, results in IgA deficiency in the recipient. This recipient had normal IgA levels prior to transplant. Both the recipient and donor demonstrated the presence of IgA genes and it was speculated that the IgA deficiency is manifested at stem cell level.
Imputability grade: 
2 Probable
Groups audience: 
Suggest new keywords: 
IgA Deficiency
Bone marrow transpantation
Stem cell transplantation
Acquired Deficiency
Reference attachment: 
Suggest references: 
Hammarstrom, L., Lonnqvist, B., Ringden, O., Smith, C. I. and Wiebe, T. (1985). Transfer of IgA deficiency to a bone-marrow-grafted patient with aplastic anaemia. Lancet 1:778. Kurobane I, Riches PG, Sheldon J, Jones S, Hobbs JR. (1991). Incidental correction of severe IgA deficiency by displacement bone marrow transplantation. Bone Marrow Transplant. 7:494.
Expert comments for publication: 
One of the few published case of transfer of selective IgA deficiency by marrow transplantation.There are other case reports that demonstrate correction of IgA deficiency in a marrow transplant recipient after transplantation from a donor who had no IgA deficiency