TRALI (Transfusion Related Acute Lung Injury)

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Estimated frequency: 
Retrospective cohort study at Mayo Clinic 1.3 -1.4% of non-cardiac surgery transfused patients
Time to detection: 
<6 hours
Alerting signals, symptoms, evidence of occurrence: 
2004 Canadian consensus conference criteria
Demonstration of imputability or root cause: 
TRALI and Possible TRALI criteria; records reviewed rather than relying on passive reporting (which provided no reported cases)
Imputability grade: 
2 Probable
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Reference attachment: 
Suggest references: 
Clifford, L., Jia, W., Subramanian, A., Tadav, H., Wilson, G.A., Murphy, S.P., Pathak, J. Schroeder, D. R. and Kor, D.J. (2015). Characterizing the Epidemiology of Postoperative Transfusion-related Acute Lung Injury. Anesthesiology 122(1):12-20
Expert comments for publication: 
0/45 TRALI or possible TRALI cases were reported to the transfusion service. Perioperative TRALI/possible TRALI is more common than previously reported and its risk increases with greater volumes of blood component therapies.