Naegleria fowleri

Status:

Ready to upload

Record number:

1469

Adverse Occurrence type:

Donor disease without transmission

MPHO Type:

Multiple types or not specified

Estimated frequency:

None to date

Time to detection:

N/A

Alerting signals, symptoms, evidence of occurrence:

During 1995–2012, 21 recipients of solid organs from 5 donors with fatal primary amebic meningoencephalitis (PAM) were reported in the United States. None of the recipients developed PAM and several recipients tested negative for N. fowleri by serology. Only 1 lung recipient received IV amphotericin prophylactically but due to renal intolerance, the drug was stopped within two days. Historical PAM case reports and animal experiments with N. fowleri, combined with new postmortem findings from four patients with PAM, suggest that extra-CNS dissemination of N. fowleri can occur and might pose a risk for disease transmission via transplantation.

Demonstration of imputability or root cause:

No transmission occured in any of the reported cases.

Groups audience:

Infections -- Parasitic

Infections

Keywords:

donor disease without documented transmission

SOT (solid organ transplantation)

Naegleria fowleri

PAM (primary amebic meningoencephalitis)

IWDT (intervention without documented transmission)

References:

Risk for Transmission of Naegleria fowleri From Solid Organ Transplantation.

Emerging trends in free-living amebic infections of the brain: implications for organ transplantation.

Use of organs for transplantation from a donor with primary meningoencephalitis due to Naegleria fowleri.

Kidney and liver transplants from a donor infected with Naegleria fowleri

Reference attachment:

Naegleria, Roy, 2014.pdf

Suggest references:

- Roy SL; Metzger R; Chen JG; Laham FR; et al. Risk for Transmission of Naegleria fowleri From Solid Organ Transplantation. American Journal of Transplantation 2014; 14: 163-171