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Adverse Occurrence type:
Time to detection:
Alerting signals, symptoms, evidence of occurrence:
Donor positive smear on day +26; PCR positive on day +19. Interpreted by authors as reactivation since donor was not in a malaria endemic zone at the time. When malaria was diagnosed in the donor, the recipient was on day +26 and asymptomatic. No documented infection in recipient, who received prophylaxis once donor found to be positive for P. vivax.
Demonstration of imputability or root cause:
Intervention without documented transmission (IWDT): recipient monitored by blood smears and PCR, never positive, received chloroquine 25mg/kg for 3 days prophylatically. Very difficult to determine if the donor was positive at the time of transplantation. The authors supposed the donor could be infected as he was not living in endemic zone at the time of diagnosis.
Inoue J, Machado CM, Lima GF, Nascimento Mde J, Colturato VR, Di Santi SM. The monitoring of hematopoietic stem cell transplant donors and recipients from endemic areas for malaria. Rev Inst Med Trop Sao Paulo. 2010 Sep-Oct;52(5):281-4.
The infecton in the donor at the time of transplantation is supposed but not demostrated. Thus, any kind of consideration for transmission to the donor is merely an assumption.