Status:
Ready to upload
Record number:
1443
Adverse Occurrence type:
MPHO Type:
Estimated frequency:
Case report
Alerting signals, symptoms, evidence of occurrence:
Retrospectively screened, 1 of 20 multipotent mesenchymal stromal cells (MSCs) from healthy donors contained parvovirus B19 (B19) DNA. Two patients undergoing HSCT received the B19-positive MSCs as treatment for graft-versus-host disease; One of the donor–recipient pairs was mis-matched in terms of B19 serology; No B19 seroconversion occurred nor symptomatic B19 infection, and no B19 DNA was detected in the blood after MSC transplantation. The patients died, one due to relapse and the other due to septicemia, neither of which was likely related to infusion of B19-positive MSCs. These findings demonstrate for the first time that persistent B19 in MSCs can infect hematopoietic stem cells and underscore the importance of monitoring B19 transmission by MSC products.
Demonstration of imputability or root cause:
No transmission/disease occured.
Groups audience:
Keywords:
Suggest new keywords:
Parvovirus B19, B19, MSC, Mesenchymal Stem Cells,
Reference attachment:
Suggest references:
M. Sundin, A. Lindblom et al (2008). Persistence of human parvovirus B19 in multipotent mesenchymal stromal cells expressing the erythrocyte P antigen: implications for transplantation.Biology of blood and marrow transplantation; Biol Blood Marrow Transplant 14 (10): 1172-9 (Review).
Note:
This is a risk of harm case with no transmission. However it could go into the disease without transmission category (donor disease without documented transmission)
ADD Cells/Mesenchymal stem cells IN THE MPHO TAXONOMY (EP)