Human T-lymphotropic Virus HTLV I

Status: 
Ready to upload
Record number: 
1439
Adverse Occurrence type: 
Human T-lymphotropic Virus (HTLV)
MPHO Type: 
Whole blood
Time to detection: 
19 days
Alerting signals, symptoms, evidence of occurrence: 
No HTLV-related symptoms. Infection detected through routine follow up screening for blood borne viruses following emergency transfusion of unscreened blood after sustaining severe injuries whilst in combat. Screening is done according to US miltary protocol. Antibody reactivity detected at 19 days and confirmed at 22 days post transfusion.
Demonstration of imputability or root cause: 
Recipient showed initial antibody reactivity at day 19 post transfusion, with an indeterminate Western Blot pattern; fully confirmed seroconversion on day 44. Donor found to be seropositive. Molecular markers relatedness of donor and recipient strains demonstrated by sequencing.
Imputability grade: 
3 Definite/Certain/Proven
Groups audience: 
Infections -- Viral
Infections
Keywords: 
HTLV I (human T-lymphotropic virus type I)
whole blood
asymptomatic
screening
seroconversion
sequencing
emergency transfusion
unscreened blood
References: 
Transfusion-transmitted human T-lymphotropic virus Type I infection in a United States military emergency whole blood transfusion recipient in Afghanistan, 2010.
Suggest new keywords: 
emergency transfusion
unscreened blood
Reference attachment: 
PDF icon _ HTLV I, Hakre, 2013.pdf
Suggest references: 
Shilpa Hakre, Mark M. Manak, Clinton K, et al. Transfusion-transmitted human T-lymphotropic virus Type I infection in a United States military emergency whole blood transfusion recipient in Afghanistan, 2010. TRANSFUSION 2013;53:2176-2182.