Status:
Ready to upload
Record number:
1428
Adverse Occurrence type:
MPHO Type:
Time to detection:
hours
Alerting signals, symptoms, evidence of occurrence:
HHV6 DNA load in plasma on days - 32, - 14, and - 27 was negative, but appeared positive only a few hours after cord blood stem cell infusion (day 0). Antiviral treatment ineffective. Asymptomatic.
Demonstration of imputability or root cause:
Chromosomal integration of the HHV-6 genome (CIHHV-6) was suspected. Cord blood unit-derived DNA was highly HHV6 DNA positive (10^7 copies/mL) in various cell populations. Hair follicles were negative for HHV6 DNA, indicating that the recipient is CI-HHV6 negative. FISH analysis of chromosome preparations made from phytohemagglutinin-stimulated peripheral blood cultures revealed CI-HHV6 on the telomeric site of the long arm of chromosome 9.
Imputability grade:
3 Definite/Certain/Proven
Groups audience:
Keywords:
Reference attachment:
Suggest references:
de Pagter PJ, Virgili A, Nacheva E, et al. Chromosomally integrated human herpesvirus 6: transmission via cord blood-derived unrelated hematopoietic stem cell transplantation. Biol Blood Marrow Transplant. 2010 Jan;16(1):130-2.