Human herpes virus 6 (HHV-6)

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Record number: 
Adverse Occurrence type: 
MPHO Type: 
Time to detection: 
10 days
Alerting signals, symptoms, evidence of occurrence: 
HHV6 DNA detected in serum (up to 200.000 copies/ml). Despite antiviral treatment, HHV-6 copy numbers remained unchanged. Asymptomatic.
Demonstration of imputability or root cause: 
Chromosomal integration of the HHV-6 genome (CIHHV-6) was suspected. HHV-6 DNA was detectable in donor lymphocytes (PCR). FISH analysis of peripheral blood leukocytes of the patient and of donor lymphocytes demonstrated integration of HHV-6 DNA in all analyzed cells at the telomere region of the short arm of one homologue of chromosome 17 (ter 17p).
Imputability grade: 
3 Definite/Certain/Proven
Reference attachment: 
Suggest references: 
Strenger V, Urban C, Schwinger W, Nacheva EP, Aberle SW. Transmission of chromosomally integrated HHV-6 by bone marrow transplantation. Pediatr Blood Cancer. 2011 Jan;56(1):171.