Human herpes virus 6 (HHV-6)

Status:

Ready to upload

Record number:

1426

Adverse Occurrence type:

Human Herpes Virus 6 (HHV-6)

MPHO Type:

Marrow

Time to detection:

10 days

Alerting signals, symptoms, evidence of occurrence:

HHV6 DNA detected in serum (up to 200.000 copies/ml). Despite antiviral treatment, HHV-6 copy numbers remained unchanged. Asymptomatic.

Demonstration of imputability or root cause:

Chromosomal integration of the HHV-6 genome (CIHHV-6) was suspected. HHV-6 DNA was detectable in donor lymphocytes (PCR). FISH analysis of peripheral blood leukocytes of the patient and of donor lymphocytes demonstrated integration of HHV-6 DNA in all analyzed cells at the telomere region of the short arm of one homologue of chromosome 17 (ter 17p).

Imputability grade:

3 Definite/Certain/Proven

Groups audience:

Infections -- Viral

Infections

Keywords:

HHV6 (human herpes virus 6)

asymptomatic

CIHHV-6 (chromosomally integrated human herpesvirus 6)

PCR (polymerase chain reaction)

FISH (fluorescence in situ hybridization)

marrow

HSC (hematopoietic stem cells)

References:

Transmission of chromosomally integrated HHV-6 by bone marrow transplantation.

Transmission of integrated human herpesvirus-6 in allogeneic hematopoietic stem cell transplantation.

Reference attachment:

_ _ HHV-6, Strenger, 2011.pdf

Suggest references:

Strenger V, Urban C, Schwinger W, Nacheva EP, Aberle SW. Transmission of chromosomally integrated HHV-6 by bone marrow transplantation. Pediatr Blood Cancer. 2011 Jan;56(1):171.

Note: